Journal of Animal Behaviour and Biometeorology
http://www.jabbnet.periodikos.com.br/article/doi/10.31893/jabb.21027
Journal of Animal Behaviour and Biometeorology
Research Article Open Access

Administration of curcumin affects the anxiety behavior in Wistar rats after formaldehyde injected

Mouna Nouacer, Amira Bakeche, Ibtissem Chouba, Abdelkrim Tahraoui

Downloads: 0
Views: 166

Abstract

The curcumin is part of the curcuminoids family. Present in the spice turmeric is a vegetable alkaloid obtained from Curcuma longa. Many studies have been carried out to describe the multiple biological actions of curcumin. The positive antidepressant and anti-anxiety effects of curcumin are most likely due to its ability to normalize specific physiological mechanisms, in addition to being a potent antioxidant and anti-inflammatory agent. Curcumin also protects the brain and simultaneously acts on several mechanisms related to depression. It is considered to be the most promising therapeutic target for treating depressive behaviors. Through this work, we will prove the protective effect of curcumin on the anxious behavior of Wistar rats and the complications induced by the administration of a toxic product that is formaldehyde. To this fact, 25 white rats of Wistar strains (250±50 g) were separated into five experimental batches: control batch (T; n = 5), vehicle control batch (CV; n = 5), Curcumin control batch (CC; n = 5), one batch formaldehyde vehicle (FV; n = 5) and one batch formaldehyde Curcumin (FC; n = 5). A single intraperitoneal injection carried out the formaldehyde administration diluted in distilled water at a dose of 10 mg/kg. Turmeric dissolved in olive oil was administered by gastric gavage at a dose of (60 mg/kg). Our results show the therapeutic benefits of curcumin against the deficits caused by formaldehyde reflected in a disturbance in rat behavior and degree of anxiety using the open-field test and the light and dark box test.

Keywords

animal behavior, anxiety, Curcuma longa, open-field test, tumeric

References

Arrant AE, Jemal H, Kuhn CM (2013) Adolescent male rats less sensitive than adults are to the antigenic and serotonin releasing effects of fenfluramine. Neuropharmacology 65:213-22.

Ben Ahmed A (2016) Etude de l’activite anxiolytique de l’extrait pib001 chez la souris. Mémoire de master, Université D’Antananarivo.

Choi GY, Kim HB, Hwang ES, Lee S, Kim MJ, Choi J Y, Lee SO, Kim SS, Park JH (2017) Curcumin alters neural plasticity and viability of intact hippocampal circuits and attenuates behavioral despair and COX-2 expression in chronically stressed rats. Mediators of inflammation.

Erika R (2015) ANALYSE DU MARCHÉ IMMOBILIER MONTRÉALAIS : LA PLACE DU BÂTIMENT DURABLE Essai présenté au Centre universitaire de formation en environnement et développement. Maîtrise en environnement. Centre Universitaire de Formation en environnement et développement durable.

Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour-Mobarhan M (2015) An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chinese journal of integrative medicine 21:332-338.

Hall CS (1934) Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality. Journal of Comparative Psychology 18:385–403.

Hoque HMS, Irie H, Damiani A, Rawat P, Naja M (2018) First simultaneous observations of formaldehyde and glyoxal by MAX-DOAS in the Indo-Gangetic Plain region. Sola 14:159-164. doi.org/10.2151/sola.2018-028.

Huang Z, Zhong XM, Li ZY, Feng CR, Pan AJ, and Mao QQ (2011) Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neuroscience letters 493:145-148.

Lan Q , Smith MT, Tang X , Guo W, Vermeulen R, Ji Z, Hu W,Hubbard AE, Shen M, McHale CM, Qiu C , Liu S , Reiss B ,Beane-Freeman L , Blair A, Ge Y ,Xiong J , Li L ,Rappaport SM,Huang H, Rothman N , Zhang L (2015) Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. Carcinogenesis 36:160–167.

Lee B, Lee H (2018) Systemic administration of curcumin affect anxiety-related behaviors in a rat model of posttraumatic stress disorder via activation of serotonergic systems. Evidence-Based Complementary and Alternative Medicine.

Li Y, Song Z, Ding Y, Xin Y, Wu T, Su T, He R, Tai F, Lian Z (2016) Effects of formaldehyde exposure on anxiety-like and depression-like behavior, cognition, central levels of glucocorticoid receptor and tyrosine hydroxylase in mice. Chemosphere 144:2004-2012.

Lopresti AL, Drummond PD (2017) Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. Journal of affective disorders 207:188-196.doi.org/10.1016/j.jad.2016.09.047

Mahmoud AL, Fenghour M (2016) Etude de l'effet protecteur d’un produit de la ruche, la gelée royale sur le Stress oxydatif et l’inflammation induit par le formaldéhyde chez le rat. Université des Frères Mentouri Constantine.

Morrone MDS, Schnorr CE, Behr GA, Gasparotto J, Bortolin RC, Moresco KS, Bittencourt L, Zanotto-Filho A, Gelain DP, Moreira JCF (2016) Oral administration of curcumin relieves behavioral alterations and oxidative stress in the frontal cortex, hippocampus, and striatum of ovariectomized Wistar rats. The Journal of nutritional biochemistry 32:181-188.

Motterlini R, Foresti R, Bassi R, Green CJ (2000) Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radical Biology and Medicine 28:1303-1312.

Usanmaz SE, Akarsu ES, Vural N (2002) Neurotoxic effects of acute and subacute formaldehyde exposures in mice. Environmental Toxicology and Pharmacology 11:93-100.doi.org/10.1016/S1382-6689(01)00109-.

Wang X, He R (2017) Formaldehyde Exposure and Neuropsychiatric Disorders. Formaldehyde and Cognition 191–207. Doi10.1007978-94-024-1177-5_10. 

World Health Organization (2017) Depression and other common mental disorders: Global health estimates. Geneva: World Health Organization.

Yow HY, Ahmad N, Azmi N, Bakry MM (2017) the effect of curcumin on anxiety and recognition memory in kainate model of epileptic rats. Indian Journal of Pharmaceutical Sciences 79:267-276.


Submitted date:
03/10/2021

Reviewed date:
03/25/2021

Accepted date:
03/27/2021

605f4643a953950ac904d2b3 jabbnet Articles
Links & Downloads

J Anim Behav Biometeorol

Share this page
Page Sections